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non selective 5 ht 2 receptor antagonist  (BOC Sciences)


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    BOC Sciences non selective 5 ht 2 receptor antagonist
    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).
    Non Selective 5 Ht 2 Receptor Antagonist, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/non+selective+5+ht+2+receptor+antagonist/5-HT2+antagonist+1/pmc09558739-55-3-11
    Average 93 stars, based on 2 article reviews
    non selective 5 ht 2 receptor antagonist - by Bioz Stars, 2026-09
    93/100 stars

    Images

    1) Product Images from "Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling"

    Article Title: Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2022.968976

    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).
    Figure Legend Snippet: Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Techniques Used: Tail Flick Test

    Related Articles

    Tail Flick Test:

    Article Title: Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling
    Article Snippet: Decursinol was diluted into a 125 mg/ml stock solution using dimethyl sulfoxide (DMSO; 679; Fisher Scientific, Pittsburgh, PA).Decursinol was diluted into a 125 mg/ml stock solution using dimethyl sulfoxide (DMSO; 679; Fisher Scientific, Pittsburgh, PA).. Methysergide maleate, a non-selective 5-HT 2 receptor antagonist, was obtained from BOC Sciences (5281073; Shirley, NY) while the 5-HT 2A receptor antagonist volinanserin (5311271), the 5-HT 2C antagonist SB-242084 (3644637), the nonselective opioid antagonist naloxone hydrochloride (5464092), the CB 1 inverse agonist rimonabant hydrochloride (104849), and the CB 2 inverse agonist SR144528 (3081355) were all obtained from Cayman Chemical (Ann Arbor, MI).. Methysergide was dissolved in DMSO, naloxone in saline, and all other drugs were dissolved in ethanol.Methysergide was dissolved in DMSO, naloxone in saline, and all other drugs were dissolved in ethanol.



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    non selective 5 ht 2 receptor antagonist  (BOC Sciences)
    93
    BOC Sciences non selective 5 ht 2 receptor antagonist
    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).
    Non Selective 5 Ht 2 Receptor Antagonist, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/non+selective+5+ht+2+receptor+antagonist/5-HT2+antagonist+1/pmc09558739-55-3-11
    Average 93 stars, based on 1 article reviews
    non selective 5 ht 2 receptor antagonist - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Journal: Frontiers in Pharmacology

    Article Title: Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling

    doi: 10.3389/fphar.2022.968976

    Figure Lengend Snippet: Serotonin Receptor 2 (5-HT 2 ) signaling does not attenuate decursinol-induced antinociception or hypothermia. Mediation of the acute antinociceptive (A/B) and hypothermic (C) effects of 50 mg/kg decursinol by 5-HT 2 antagonists in male mice. Mice (N = 10) were assessed for hot plate (A) and tail-flick (B) antinociception (%MPE) and hypothermia (C; %ΔBT) 30 min following pretreatment with either vehicle (VEH), 4 mg/kg of the non-selective 5-HT 2 antagonist Methysergide (MS), 4 mg/kg of the selective 5-HT 2A antagonist Volinanserin (5-HT 2A ), or 4 mg/kg of the selective 5-HT 2C receptor antagonist SB-242084 (5-HT 2C ) and again 30 min following treatment with either vehicle (VEH; unfilled bars) or 50 mg/kg of decursinol (DOH; filled bars). Error bars represents the mean ± SEM. Data were analyzed using a repeated measures one-way ANOVA with Bonferroni post-hoc tests (*** p < 0.001; **** p < 0.0001 compared to VEH/VEH; # p < 0.05 compared to VEH/DOH).

    Article Snippet: Methysergide maleate, a non-selective 5-HT 2 receptor antagonist, was obtained from BOC Sciences (5281073; Shirley, NY) while the 5-HT 2A receptor antagonist volinanserin (5311271), the 5-HT 2C antagonist SB-242084 (3644637), the nonselective opioid antagonist naloxone hydrochloride (5464092), the CB 1 inverse agonist rimonabant hydrochloride (104849), and the CB 2 inverse agonist SR144528 (3081355) were all obtained from Cayman Chemical (Ann Arbor, MI).

    Techniques: Tail Flick Test